John Latham

Assistant Professor

What I do

My lab is currently focused on solving the structure, function, and biosynthesis of the unknown Mycobacterial metabolite dubbed mycofactocin.

Professional Biography

PhD - University of New Mexico (2012)
Postdoc - University of California, Berkeley (2013-15)

Degree(s)

  • Ph.D., Chemistry, University of New Mexico, 2012
  • MS, Chemistry, Eastern New Mexico University, 2008
  • BS, Chemistry, Eastern New Mexico University, 2007

Licensure / Accreditations

  • New Mexico Teaching Liscensure

Featured Publications

Khaliullin, B., Aggarwal, P., Bubas, M., Eaton, G. R., Eaton, S. S., & Latham, J. (2016). Mycofactocin biosynthesis: modification of the peptide MftA by the radical S-adenosylmethionine protein MftC. FEBS letters, 590(16), 2538–2548.
Ayikpoe, R., Salazar, J., Majestic, B. J., & Latham, J. (2018). Mycofactocin biosynthesis proceeds through 3-amino-5-[(p-hydroxyphenyl) methyl]-4,4-dimethyl-2-pyrrolidinone (AHDP); direct observation of MftE specificity towards MftA*. Biochemistry, 57, 5379-5383.
Ayikpoe, R., Ngendahimana, T., Langton, M., Bonitatibus, S., Walker, L. M., Eaton, S. S., et al. (2019). Spectroscopic and Electrochemical Characterization of the Mycofactocin Biosynthetic Protein, MftC, Provides Insight into its Redox Flipping Mechanism. Biochemistry.
Ayikpoe, R. S., & Latham, J. (2019). MftD Catalyzes the Formation of a Biologically Active Redox Center in the Biosynthesis of the Ribosomally Synthesized and Post-translationally Modified Redox Cofactor Mycofactocin. Journal of the American Chemical Society, 141, 13582-13591.